If you’re the kind of traveler who loves a hotel that doubles as an Instagrammable art moment and a sanctuary of design-forward, luxe creature comforts, let us introduce you to your new hotel crush: 21c Museum Hotel St Louis.
Housed in a beautifully restored century-old Renaissance Revival-style former YMCA building, this 10-story stay brings together bold contemporary art, hyper-local culture, and elevated hospitality under one seriously photogenic roof. Think: art museum by day, boutique hotel by night.
What makes the 21c Museum Hotel St. Louis so unique is the way it honors its architectural history without being tied to it. The renovation is a masterclass in preservation meets modern indulgence—historic stonework, soaring ceilings, and original details (like basketball courts) layered with sleek finishes, curated lighting, and avant-garde touches that feel fresh.
Idol Wolf, the on-site restaurant, is a Spanish-influenced dreamscape where tapas-style plates meet thoughtful cocktails in a space that feels part Madrid, part Midwest. So, post up with jamón and vermouth and enjoy the cultural clash. Good Press, the hotel’s café concept, leans more casual but no less curated, perfect for your oat milk cortado and flaky pastry moment.
The Locust Street Athletic and Swim Club is 10,000+ square feet of vintage gym charm meets next-level wellness. There’s a mosaic tiled pool, steam room, sauna, and fully loaded fitness center—all paying homage to the building’s YMCA roots.
Art isn’t just an accent here—it’s the whole experience. From the moment you walk through the doors, you’re greeted with curated installations, rotating exhibitions, and statement-making pieces from regional and national contemporary artists. The guest rooms? Minimalist chic with surprise details and original works that make you feel like you’re staying inside a living gallery. (Because you kind of are.) The hotel’s gallery space is over 14,000 square feet and currently features the latest exhibit, Pop Stars! Popular Culture and Contemporary Art, with 90 pieces from 55 artists worldwide.
Top Takeaways
Location: St. Louis, Missouri, USA
Rating: Four-star
The vibe: Historic charm meets contemporary, artistic flair
Food + drink: on-site cafe with pastries and coffee, Spanish-inspired eatery with creative cocktails and tapas-style offerings
Amenities: Restaurant, Bar, Spa, Pool, Coffee shop, and Valet.
Our favourite thing about the hotel: The magical multi-story ombre mural climbing from the lobby
What’s nearby: St. Louis is a celebrated culinary city, so plan a foodie tour of the area. Visit Louie’s in Clayton for roast chicken that will change your life. Try None of the Above for the most inventive cocktails in town. Go to Webster Groves for comforting, award-winning Bosnian fare at Balkan Treat Box. Try Sado for divine Japanese bites. Be sure to visit The Gateway Arch, one of the only urban national parks in the United States.
Any personal neighbourhood recs? The weird and wonderful City Museum is just down the block. This former shoe factory turned trippy, artist-built playground is an iconic St. Louis stop. Don’t miss the rooftop Ferris wheel for the ultimate city views.
Rooms: 173
Pricing: Rates start at $239 per night.
Closest international airport: St. Louis Lambert International Airport (STL) is roughly 15 miles from the property.
