April 20, also known as 4/20, is fast approaching, and luxury hotels are blazing a new trail in high-end hospitality. What started as an underground celebration for cannabis enthusiasts has officially gone upscale, with high-end properties rolling out curated, THC-friendly experiences that feel more five-star than fringe. From CBD-infused soaks and THC massages to gourmet menus crafted with the munchies in mind, these stays are redefining wellness with a cannabis twist. Whether the backdrop is desert chic or mountain hideaway, one thing’s clear: weed and wellness are the new it-pair, and hotels are all in. Keep reading to uncover some of the best cannabis-infused hotel offerings out there–it's high time for a vacation, after all.
Salish Lodge & Spa
Just 30 minutes outside of Seattle, Salish Lodge & Spa is a cozy escape sitting high on the Snoqualmie Falls—and now it’s adding a little extra bliss to the mix. The Canna’Bliss spa menu puts high-end CBD front and center, thanks to a range of soothing massages, body polishes, and bath rituals designed to ease tension, reduce inflammation, and leave skin glowing. Think: a lavender and sweet orange sugar scrub, or a gold-infused CBD oil massage that melts stress without the high. (For those sticking to the classic treatments, a CBD add-on can be tacked onto most services.) Pair it all with the spa’s soaking pools, eucalyptus steam room, and oversized tubs overlooking the falls, and Salish is a wellness experience unlike any other.
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Key Points:
Rating: 4 Stars
Rooms: 86 rooms
Airport: Seattle-Tacoma International Airport (SEA)
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Amenities:
Gas fireplaces
Premium mattresses with gel memory foam and extra-thick plush top quilting
Salish Lavender Mint shampoo, conditioner, body wash, lotion, and soap
Daily newspaper
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The Madrones
The Madrones in Anderson Valley has an effortlessly cool vibe—think wine country charm with a little bohemian flair. One of the standout features? The Bohemian Chemist, an on-site apothecary with small-batch, sun-grown cannabis. It started when the owner’s 90-year-old mom passed down her cannabis patch, and now guests can check out beautifully packaged flower, pre-rolls, and other items from local legacy farmers. For a deeper dive, guests can also head over to Sugar Hill Farm, The Bohemian Chemist’s nearby grow operation. It has great views, a laid-back energy, and a front-row seat to sustainable cannabis cultivation. A weekend here feels both relaxing and refreshing, with just the right buzz.
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Key Points:
Rating: 4 Stars
Rooms: 10 rooms
Airport: Charles M. Schulz–Sonoma County Airport (STS)
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Amenities:
Two tasting rooms
Sun & Cricket show
Baths
Pet-friendly
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The Beach Samui
The Beach Samui is that kind of place where wellness actually feels like a treat, not a to-do list. Tucked away on the southern coast of Koh Samui (yes, the island where Season 3 of The White Lotus was just filmed), this boutique retreat knows how to do relaxation right. Their wellness game is strong, especially with a lineup of cannabis-infused treatments that are designed to totally reset the mind and body. Whether it’s a sound healing session paired with a Kanha gummy or an indica-infused sleep ritual that ends in a dreamy in-bed massage, these treatments are sure to calm any stressed traveler down. What’s more, there’s everything from vibroacoustic massage to sunset yoga at an elephant sanctuary—plus a team of herbal pharmacists, guest practitioners, and staff to help tailor it all to guests’ moods. Trust us, you’ll leave better than you came.
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Key Points:
Rating: 5 Stars
Rooms: 21 rooms
Airport: Samui International Airport (USM)
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Amenities:
Pool
Herbalist
Restaurant
Range of Experiences
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The Tryall Club
The Tryall Club in Montego Bay is already a dreamy escape, but their spa takes things to another level with a farm-to-spa approach that brings the island straight to the treatment table. Their wellness offerings are infused with local ingredients, including Jacana CBD products sourced from organically grown cannabis in the nearby St. Ann mountains. Not to mention, even the hotel’s juice shots are mixed with healing ingredients and seasonal fruits, meaning guests will be glowing from the inside out.
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Key Points:
Rating: 5 Stars
Rooms: 74 rooms
Airport: Montego Bay (MBJ)
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Amenities:
Private shoreline
Exclusive golf club
Spa
Restaurants and bars
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Mendocino Grove
Mendocino Grove, a glamping destination in Northern California’s coastal woods, is setting the stage for a cannabis-infused weekend that’s anything but ordinary. From April 18–20, 2025, they’re partnering with Cannescape, a travel-focused cannabis dining company, for a two-night retreat that blends nature, wellness, and good vibes. Renowned chef Haejin Chun, a first-generation Korean American and cannabis culinary expert, is curating infused multi-course meals to pair with the weekend and events. Beyond the bites, the weekend includes morning wellness workshops, skin-care sessions with Green Bee Botanicals, and time with local Mendocino makers. Book the 420 Experience here.
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Key Points:
Rating: 5 Stars
Rooms: 60 rooms
Airport: Charles M. Schulz Sonoma County Airport (STS)
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Amenities:
Heated beds
Decks
Butterfly chairs
Critter-safe food storage
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Avani+ Samui Resort
Looking for a tropical escape? Avani+ Samui Resort, located on Koh Samui’s quiet north-eastern coast, is the perfect spot. With spacious rooms, tons of waterfront to enjoy, and nearby markets and temples to explore, it has that laid-back vibe that makes it the ultimate place to unwind. The CBD treatments here are the cherry on top, taking relaxation to a whole new level. Whether it’s the Head-to-toe Cannamelt with a soothing CBD scrub and balm to ease muscle aches, or the Out-of-Office Canna Escape designed to tackle back and neck pain, every treatment keeps stress at bay. Simply put, it's the ideal place to reset and recharge.
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Key Points:
Rating: 5 Stars
Rooms: 58 rooms
Airport: Samui International Airport (USM)
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Amenities:
Private balconies
Rain showers
Bluetooth speakers
Beachfront
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St Julien Hotel & Spa
The St Julien Hotel & Spa is one of Boulder’s most iconic stays–right at the base of the Flatirons, just steps from Pearl Street. The vibe here is relaxed luxury: think nice rooms with incredible mountain views and a location that makes it easy to explore the best of Boulder without ever needing a car. There's a great restaurant and bar on-site, live music some evenings, and a cozy courtyard that’s especially dreamy in warmer months. However, the real magic happens at the spa. Their CBD-infused services include deep tissue massages, facials, and even pedicures. Bonus: the spa has a steam room, sauna, pool, hot tub, and fitness center, so it’s easy to make a whole day of it.
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Key Points:
Rating: 5 Stars
Rooms: 201 rooms
Airport: Denver International Airport (DEN)
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Amenities:
Restaurant
Courtyard
Occasional live music
Mountain views
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